ACHB3 Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: RA30976-50, RA30976-100

Citations, Manuals and MSDS Available upon request.

Background: cholinergic receptor nicotinic beta 3 subunit (CHRNB3) Homo sapiens The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The nAChRs are (hetero) pentamers composed of homologous subunits. The subunits that make up the muscle and neuronal forms of nAChRs are encoded by separate genes and have different primary structure. There are several subtypes of neuronal nAChRs that vary based on which homologous subunits are arranged around the central channel. They are classified as alpha-subunits if, like muscle alpha-1 (MIM 100690), they have a pair of adjacent cysteines as part of the presumed acetylcholine binding site. Subunits lacking these cysteine residues are classified as beta-subunits (Groot Kormelink and Luyten, 1997 [PubMed 9009220]) . Elliott et al. (1996) [PubMed 8906617] stated that the proposed structure for each subunit is a conserved N

Condition: Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Storage Instructions: -20°C/1 year

Recommended dilutions: WB 1:500-2000 ELISA 1:5000-20000

Applications: WB; ELISA

Species Cross-Reactivity: Human; Mouse; Rat

GeneID (Human): 1142

Protein MW (KDa): 50

SWISS: Q05901

Source: Rabbit

Research Use Only