FPPQ is a Dual-Acting 5‑HT3 (K1 = 0.9 nM) and 5‑HT6 (Ki = 3 nM) Receptor Antagonist with Antipsychotic and Procognitive Properties. FPPQ behaves as a 5-HT3R antagonist and a neutral antagonist 5-HT6R of the Gs pathway. FPPQ shows selectivity over 87 targets and decent brain penetration. Likewise, FPPQ inhibits phencyclidine (PCP)-induced hyperactivity and displays procognitive properties in the novel object recognition task. FPPQ is a dual-acting 5-HT3 (Ki = 0.9 nM) and 5-HT6 (Ki = 3 nM) receptor antagonist with antipsychotic and procognitive properties.

Product information

CAS Number: 1648745-46-3

Molecular Weight: 410.46

Formula: C21H19FN4O2S

Chemical Name: 1-[1-(3-fluorobenzenesulfonyl)-1H-pyrrolo[3, 2-c]quinolin-4-yl]piperazine

Smiles: O=S(=O)(C1=CC(F)=CC=C1)N1C=CC2=C(N=C3C=CC=CC3=C12)N1CCNCC1

InChiKey: QNKGTIWNFNPEJL-UHFFFAOYSA-N

InChi: InChI=1S/C21H19FN4O2S/c22-15-4-3-5-16(14-15)29(27,28)26-11-8-18-20(26)17-6-1-2-7-19(17)24-21(18)25-12-9-23-10-13-25/h1-8,11,14,23H,9-10,12-13H2

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: To be determined

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

1. Zajdel P, et al. Structure-Based Design and Optimization of FPPQ, a Dual-Acting 5-HT3 and 5-HT6 Receptor Antagonist with Antipsychotic and Procognitive Properties. J Med Chem. 2021 Sep 23;64(18):13279-13298.

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