D-Galactosamine HCl is a galactose-derived hexosaine sugar and component of FSH and LH. It is used to induce endotoxic shock. D(+)-Galactosamine (D-Galactosamine) hydrochloride, which is an established experimental toxin, primarily causes liver injury by the generation of free radicals and depletion of UTP nucleotides. D(+)-Galactosamine hydrochloride intoxication also induces renal dysfunction thus, renal failure is often associated with the end-stage of the liver damage. Lipopolysaccharide/D(+)-Galactosamine-induced acute liver injury is a known animal model of fulminant hepatic failure.

Product information

CAS Number: 1772-03-8

Molecular Weight: 215.63

Formula: C6H14ClNO5

Chemical Name: (2R, 3R, 4R, 5R)-2-amino-3, 4, 5, 6-tetrahydroxyhexanal hydrochloride

Smiles: Cl.N[C@@H](C=O)[C@@H](O)[C@@H](O)[C@H](O)CO

InChiKey: CBOJBBMQJBVCMW-NQZVPSPJSA-N

InChi: InChI=1S/C6H13NO5.ClH/c7-3(1-8)5(11)6(12)4(10)2-9;/h1,3-6,9-12H,2,7H2;1H/t3-,4+,5+,6-;/m0./s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: To be determined

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

1. Schaff Z, Lapis K, Szendröi M. D-galactosamine-induced liver injury in immunosuppressed mice. Acta Morphol Hung. 1984;32(1):67-72. PubMed PMID: 6087623.
2. Yu T, Rhee MH, Lee J, Kim SH, Yang Y, Kim HG, Kim Y, Kim C, Kwak YS, Kim JH, Cho JY. Ginsenoside Rc from Korean Red Ginseng (Panax ginseng C.A. Meyer) Attenuates Inflammatory Symptoms of Gastritis, Hepatitis and Arthritis. Am J Chin Med. 2016;44(3):595-615. doi: 10.1142/S0192415X16500336. Epub 2016 Apr 24. PubMed PMID: 27109153.

Products are for research use only. Not for human use.