Sanggenol L induces caspase-dependent and caspase-independent apoptosis in melanoma skin cancer cells. Sanggenol L induces of apoptosis via suppression of PI3K/Akt/mTOR signaling and cell cycle arrest via activation of p53 in p

Product information

CAS Number: 329319-20-2

Molecular Weight: 424.49

Formula: C25H28O6

Chemical Name: 4-(2, 4-dihydroxyphenyl)-8-hydroxy-12-methyl-12-(4-methylpent-3-en-1-yl)-3, 11-dioxatricyclo[8.4.0.0, ]tetradeca-1, 7, 9-trien-6-one

Smiles: CC(C)=CCCC1(C)CCC2C3OC(CC(=O)C=3C(O)=CC=2O1)C1=CC=C(O)C=C1O

InChiKey: HERLGEHEPTZEHE-UHFFFAOYSA-N

InChi: InChI=1S/C25H28O6/c1-14(2)5-4-9-25(3)10-8-17-22(31-25)13-20(29)23-19(28)12-21(30-24(17)23)16-7-6-15(26)11-18(16)27/h5-7,11,13,21,26-27,29H,4,8-10,12H2,1-3H3

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: To be determined

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

1. Won YS, Seo KI. Sanggenol L Induces Apoptosis and Cell Cycle Arrest via Activation of p53 and Suppression of PI3K/Akt/mTOR Signaling in Human Prostate Cancer Cells. Nutrients. 2020;12(2):488. Published 2020 Feb 14.
2. Won YS, Seo KI. Sanggenol L promotes apoptotic cell death in melanoma skin cancer cells through activation of caspase cascades and apoptosis-inducing factor. Food Chem Toxicol. 2020;138:111221.

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